Formerly called African American AIDS Policy Training Institute, the Black AIDS Institute was founded by Phill Wilson in 1999 as a non-profit charitable organization with the goal of promoting awareness and preventing the spread of HIV/AIDS especially among the black community. Its motto has essentially remained: "Our People, Our Problem, Our Solution”.

In its early years, the institute created the African American HIV University, a training program that trains advocates to work with a wide range of organizations to influence policy, research and funding. The program consists of a 2-year fellowship including 30-day training at the AIDS Treatment College and 4 internships in several cities across the United States.

One of its most notable projects is the Black Treatment Advocates Network (BTAN), which was launched in 2010 on a Merck partnership agreement. The project aims to educate people about HIV/AIDS including the science behind its development, treatment and prevention.

The institute operates on outside funding sources with donors that include notable organizations including the Centers for Disease Control and Prevention, the Elton John AIDS Foundation, Broadway Cares/Equity Fights AIDS, the Ford Foundation, and the Magic Johnson Foundation, among others.