CureSearch for Children's Cancer is a non-profit foundation geared towards accelerating cure for children's cancer by eliminating barriers to research, solving the most challenging problems in the field, and driving innovation. Every day, the foundation strives to make treatment possible and cures feasible for the 42 children diagnosed with the disease daily. There are three ways employed by CureSearch to do this: accelerating cure for patients at greatest risk by challenging scientists and introducing novel approaches to research; supporting enrollment in clinical trials for their potential to save the day; and providing resources and education so children and their families have the support they need to face a cancer diagnosis.

CureSearch supports cancer research for children at all stages, from clinical trials to research on new treatment and fellowships for young scientists. One of the programs supported by the foundation is the Acceleration Initiative, a three-year, $5-million project aimed at addressing the most challenging barriers that are in the way of cancer research for children. By funding research that directly tackles these barriers, CureSearch believes that it will lead to significant progress in research. The Acceleration Initiative takes advantage of a flexible funding model that offers incentives to innovations in the field that often stagnate due to shortage in federal funding and delays between the laboratory and the patient. Three major research projects were chosen by CureSearch in 2013 to be supported by the Acceleration Initiative.

Operating out of a headquarters in Bethesda, Maryland, CureSearch started out as the Orion Medical Sciences Institute in 1987. It was later renamed in 1992, becoming the National Childhood Cancer Foundation before being called CureSearch for Children's Cancer in 2010. CureSearch is guided by the vision of guaranteeing a cure for every child, alleviating the plight of children as young as six years old in their fight against cancer.