To end the American “War on Drugs” has always been the advocacy of Drug Policy Alliance, a non-profit organization based in New York City. The group was founded in July 2000 after the Lindesmith Center and the Drug Policy Foundation merged.

The organization is led by their executive director Ethan Nadelmann and prioritizes the decriminalization of responsible drug use, open dialog about drugs between parents and the youth and the promotion of treatment and harm reduction in response to drug misuse. The mission of the organization is outlined as: "The Drug Policy Alliance envisions a just society in which the use and regulation of drugs are grounded in science, compassion, health and human rights, in which people are no longer punished for what they put into their own bodies but only for crimes committed against others, and in which the fears, prejudices and punitive prohibitions of today are no more.”

The Drug Policy Alliance continues to lobby for federal reforms concerning drug use. Their national affairs office is located in Washington, D. C. and they have offices in five states: New York, California, New Mexico, Colorado and in New Jersey.