Music has the power to heal. That was the driving force behind Play for Life, a music initiative created by RockCouture Productions and operated by Clear Channel Radio, in partnership with City of Hope, a National Cancer Institute-designated cancer center dedicated to finding cures for the world's worst diseases, specifically cancer. City of Hope pioneers research and technology aimed towards saving lives all over the world.

Play for Life began in 2011, a collaboration of some forty music artists, producers and directors in an all-star auction. The auction included the chance for people to meet their favorite artists and be a part of behind-the-scenes coverages, as well as taking home autographed items or items owned by participating artists. Among the more popular names involved in Play for Life were Rihanna, Justin Bieber, Matthew Morrison, Jennifer Lopez, Taylor Swift, Carrie Underwood, Rascal Flatts, Enrique Iglesias, Linkin Park, Coldplay, Colbie Caillat, Bret Michaels, Lady Antebellum, Keith Urban, Barry Manilow, the Backstreet Boys and New Kids on the Block.