The American Foundation for Children with AIDS (AFCA) is a non-profit geared towards helping children and their guardians in sub-Saharan Africa who have contracted AIDS or are HIV positive and do not have access to the medical care they need. As of 2008, sub-Saharan Africa represents over two-thirds of new HIV infections in the world and the number keeps growing. To help in the battle against HIV and AIDS, the AFCA provides critical antiretroviral medicine and other medications, medical supplies and equipment, supplements, and emergency supplies needed by various institutions in the orgnaization's targeted areas. All these are also complemented by critical support aimed at preventing HIV and AIDS which includes personnel training. At the moment, the AFCA has more than 25 partners in Zimbabwe, Uganda, Kenya, and the Democratic Republic of the Congo.

When the AFCA started, its first partners were the Mombasa Community-based Health Care and AIDS Relief Program and the St. Mary's Mission Hospital in Kenya, as well as the Mulago Hospital's Pediatric Infectious Disease Clinic in Uganda. When the organization grew, so did its list of partners, which expanded to include St. Joseph's Shelter of Hope Center and St. Theresa's Home of Hope in Kenya, the Zimbabwe Orphans through Extended Hands Program and the Church of the Ascension in Zimbabwe, the Tandala Hospital in Congo, and the Kilembe Mines Hospital, Cooley Clinic, and Mpumudde Clinic in Uganda. 

The AFCA is a part of the Children's Medical Charities of America and was recognized as the Best in America with a Seal of Excellence in 2007 from the Independent Charities of America. The Seal of Excellence is awarded to members that have withstood rigorous independent review, meeting standards set by charities and the US Government. Out of a million charities in the country, it is estimated that less than 5% meet or exceed these standards, and even fewer in that number receive the Seal of Excellence.